The safety on your rifle is not a substitute for safe gun handling but serves as a backup for momentary lapses. Even if you are carrying your rifle at “port arms” ready, you may briefly lose control of the muzzle direction if you slip or stumble. But when hiking, glassing, and even tracking, whether carrying the rifle casually or slung, the muzzle is not under tight control, so the chamber should be clear.
Whether loaded or unloaded, the muzzle must be pointed in a safe direction. When the chamber is loaded, check the mechanical safety constantly to make sure it is engaged. African hunting is especially problematic for gun handling safety because it is normal for you, your PH, and your trackers to walk single file, and you as the hunter will be well back in the line. No matter how you carry your rifle and how often you check your safety, focus on keeping the muzzle in a safe direction: UP, DOWN, or SIDEWAYS.